Preparation of Calcium Phosphate-Based Bone Repair Materials
We developed a calcium phosphate cement that could be molded into any desired shape due to its chewing-gum-like consistency after mixing. The powder component of the cement consists of tricalcium phosphate (TCP). The liquid component consists of chitosan, citric acid and glucose solution. In this study, we used four groups of cement to investigate the mechanical properties and biocompatibility of the new biomaterial in vivo. The setting times of the cements were 5-30 min. X-ray diffraction analysis showed that the products were hydroxyapatite (HA) and dicalcium phosphate anhydrous. When the concentration of citric acid was increased, the compressive strength of specimen increased. The animal experiments showed that the material was nontoxic and osteoinductivity.
calcium phosphate chitosan citric acid bone substitute material osteoinductivity
Hua Liu Jing Wang
College of Medical Information Engineering Guangdong Pharmaceutical University Guangzhou 510006,Peop Department of Orthopaedics First Affiliated Hospital of Jinan University Guangzhou 510632,Peoples R
国际会议
北京
英文
1-4
2009-06-11（万方平台首次上网日期，不代表论文的发表时间）