Synthesis and Characterization of A Novel Natural Macromolecule Antibacterial Material
A novel natural macromolecule Antibacterial material was synthesized by reaction with carboxymethylchitosan, decanoyldimethylammonium and epichlorohydrin. Long chain quaternary ammonium (OGTA) was prepared by reaction with decanoyldimethylammonium and epichlorohydrin, using isopropylalcohol as solvent, at 55 ℃ for 6 hours, and vacuum distillation. The yield was 87 percent. With 0.5g CMCTS and 2g OGTA as initiative materials, 0.5g sodium hydroxide regulating the value of PH, reacting at 30 ml Nmethylpyrrolidone for 8 hours and stirring quickly at 70 ℃ carboxymethylchitosan derivative (CMCTS-OGTA) was obtained. The yield was 95 percent. Characterization of the product by IR spectrum, 1H-NMR spectrum and element analysis revealed that the experiments had got the wanted product. Bacteriostatic activity and antibacterial activity were characterized by the greatest bacteriostatic circle method, which indicated that CMCTS-OGTA definitely had an inhibitory activity against S. aureus and bacillus subtilis. Comparation of the Bacteriostatic activities of CMCTS-OGTA and CMCTS suggested that CMCTS-OGTA had more perfect Antibacterial capability. The lowest effectively antibacterial concentrations against Bacillus coli and S. aureus were also determined.
carbozymethylchitosan quaternary ammonium bacteriostatic activity
Jianhua Sun Nannan Zheng Rongji Dai Weiwei Meng Yulin Deng
School of Life Science and Technology,Beijing Institute of Technology Beijing 100081,china
国际会议
北京
英文
1-4
2009-06-11（万方平台首次上网日期，不代表论文的发表时间）