Electrospun biodegradable nanofiber mats for controlled release of herbal medicine
Biodegradable polymer polycaprolactone (PCL; Mw～100,000) fiber mats containing shikonin from the plant Lithospermum erythrorhizon, widely known for its wound healing, anti-tumor, antioxidant, and anti-inflammatory properties, were prepared via electrosinning method. Incorporation of shikonin in the neat PCL solution did not affect the morphology of the resulting fibers, as both the neat and the shikonin-loaded PCL fibers were smooth. The shikonin release test was followed in PBS solution containing 0.5 vol.％ of Tween 80 and 10 vol.％ of methanol. The trends of the process of releaseing shikonin from the fibers with different drug loadings were similar, and showed a gradual increase in the cumulative release over the 24 h testing period. The obtained results suggested that the use of electrospun fibers as drug carriers could be promising in the future for biomedical applications.
electrospinning shikonin drug release PCL
Jie Han Hai-Tao Zhang Li-Min Zhu Christopher J Branford-White
College of Chemistry,Chemical Engineering and Biotechnology,Donghua University,Shanghai,P.R.China Institute for Health Research and Policy London Metropolitan University London,UK
国际会议
北京
英文
1-4
2009-06-11（万方平台首次上网日期，不代表论文的发表时间）