Research on Characterization and Biocompatibility of Bacterial Cellulose Tissue Engineering Scaffold
Bacterial cellulose(BC) tissue engineering scaffold, possessing nano-fiber, an ultrafine 3-dimensional network and proper porosity, has been prepared by static culture of G. xylinus. It has been characterized by scanning electron microscope (SEM), atomic force microscope (AFM), and light microscope. The pore size of BC is 0.6 to 2.6 micrometers (μm) and the width of cellulose ribbon is 50 to 80 nanometers (nm). By measuring their dry weight and wet weight, the porosities of air-dried BC and freeze-dried BC have been determined to be around 70％ and 90％ respectively; the excellent permeability of freeze-dried one has also been found to be better than PVC and PE film. The results show that it has extremely fine network of nano-structure, and the water vapor permeability is quite excellent. Cultured with fibroblasts(FBs) and chondrocytes respectively and subcutaneous transplantation of FBs-BC composition, we find that BC is suitable for cell attachment and proliferation, and shows better cell compatibility. It is expected to become a potential tissue engineering scaffold.
bacterial cellulose biocompatibility tissue engineering scaffold
Wang Zong-Liang Jia Yuan-Yuan Shi Yi Cong Deng-Li Chen Yan-Yan Jia Shi-Ru Zhou Yu-Lai
College of Pharmaceutical Sciences,Jilin University,Changchun,P.R.China State Key Laboratory of Poly College of Material Science and Chemical Engineering,Tianjin Science and technology University,Tianj College of Pharmaceutical Sciences,Jilin University,Changchun,P.R.China Key Laboratory of Industrial Microbiology,Ministry of Education,Tianjin Science and Technology Unive
国际会议
北京
英文
1-5
2009-06-11（万方平台首次上网日期，不代表论文的发表时间）