MMPs and TIMPs ezpression and the anterior cruciate ligamnent repair

摘要：

Human anterior cruciate ligament (ACL) has poor healing ability after injury. Inflammation and accumulation of matrix metalloproteinases (MMPs) in synovial fluids may be involved in the process. Tissue inhibitor metalloproteinases (TIMPs) may be independent of MMPs inhibition. A rat ACL rotating injury apparatus was designed to mimic ACL injury. ACL showed the higher MMP-1/TIMP-1 ratio after injury. Our recently findings demonstrated that MMPs expression and activities elevated significantly in the joint after ACL injury. This maybe one of the important reasons why an injured ACL cannot be repaired.

关键词： ACL MMPs TIMPs

作者: Ruyue Xue Li Yang Zhenyu Tang Jin Zhang Yequan Wang KL Paul Sung

作者单位: “111 project Laboratory of Biomechanics and Tissue Repair,Bioengineering College,Chongqing University,Chongqing 400044,China

会议类型: 国际会议

会议名称: The 3rd International Conference on Bioinformatics and Biomedical Engineering(iCBBE 2009)(第三届生物信息与生物医学工程国际会议)

会议地点: 北京

会议语种:英文

页码: 1-4

在线出版日期: 2009-06-11（万方平台首次上网日期，不代表论文的发表时间）