Regeneration of smooth muscle cells from bone marrow Use of mesenchymal stem cells for tissue engineering and cellular therapeutics
Bone marrow mesenchymal stem cells (MSCs) can differentiate into smooth muscle cells (SMCs) and have tremendous potential for cell therapy and tissue engineering. In this study, to understand the effects of TGF-β3 on rat bone marrow-derived MSCs and the underlying molecular mechanism of this differentiation process, we investigated that the changes of myocardin-related transcription factors (MRTFs) at the transcriptional level after rat MSCs were treated with TGF-β3. The results showed that TGF-β3 increased the expression of contractile genes, such as SM22, smooth muscle-myosin heavy chain (SM-MHC), SM-α-actin in MSCs. When TGF-β3 induced MSCs differentiation into SMCs, myocardin and MRTF-A were activated. The data indicated that TGF-β3 induced rat bone marrow-derived MSCs differentiation into SMCs by activating mypcardin and MRTF-A.
mesenchymal stem cells smooth muscle cells TGFβ MRTFs
Nan Wang Linlin Ma Zhen Zhou Junyun Zhang Xuegang Luo Yong Jiang Tongcun Zhang
Key Laboratory of Industrial Microbiology,Ministry of Education College of BiotechnologyTianjin Univ Key Laboratory of Industrial Microbiology,Ministry of Education College of Biotechnology Tianjin Uni
国际会议
北京
英文
1-4
2009-06-11（万方平台首次上网日期，不代表论文的发表时间）