Propylene Carbonate as a Green Solvent for Kinetic Resolution of Secondary Alcohols Catalyzed by Candida antarctica Lipase

摘要：

The kinetic resolution of secondary alcohols catalyzed by Candida antarctica lipase was studied using vinyl acetate as acyl donor in propylene carbonate. The effects of the reaction conditions included solvent, temperature, acyl donor and organic base. In the reactions, the enantioselectivity of Candida antarctica lipase increased with increasing the reaction time and the addition of triethylamine. Furthermore, it was shown that the addition of non-reactive base triethylamine to the reaction mixture enhanced the rate of the reaction. Propylene carbonate offers an environmentally friendly alternative in contrast to conventional solvents.

关键词： propylene carbonate secondary alcohols Candida antarctica lipase triethylamine

作者: Xiao-Mei Wu Li-Min Zhu Chun-Gu Xia Christopher J Branford-White

作者单位: College of Chemistry,Chemical Engineering and Biotechnology Donghua University Shanghai,China State College of Chemistry,Chemical Engineering and Biotechnology Donghua University Shanghai,China State Key Laboratory for OSSO Lanzhou Institute of Chemical Physics Chinese Academy of Sciences Lanz Institute for Health Research and Policy London Metropolitan University London,UK

会议类型: 国际会议

会议名称: The 3rd International Conference on Bioinformatics and Biomedical Engineering(iCBBE 2009)(第三届生物信息与生物医学工程国际会议)

会议地点: 北京

会议语种:英文

页码: 1-4

在线出版日期: 2009-06-11（万方平台首次上网日期，不代表论文的发表时间）