Amyloid-β Dynamics Correlate with Neurological Status in the Injured Human Brain

摘要：

The amyloid-β peptide (Aβ) plays a central pathophysiological role in Alzheimers disease, but virtually nothing is known about the concentration and dynamics of this secreted peptide in the extracellular space of the human brain. We used intracerebral microdialysis to obtain serial brain interstitial fluid (ISF) samples in 18 patients who were undergoing invasive intracranial monitoring after acute brain injury. We found a strong positive correlation between changes in brain ISF Aβ levels and neurological status, and correlations with other cerebral physiological and metabolic abnormalities reflecting depressed neuronal function. Such dynamics fit well with the hypothesis that neuronal activity regulates extracellular Aβ concentration.

关键词： amyloid beta alzheimer disease traumatic brain injury subarachnoid hemorrhage microdialysis

作者: David L.Brody Sandra Magnoni Kate E.Schwetye Michael Spinner Thomas J.Esparza Nino Stocchetti Greg J.Zipfel David M.Holtzman

作者单位: Department of Neurology,Washington University,St Louis,MO,USA Department of Anesthesia and Intensive Care,Fondazione IRCCS,Ospedale Maggiore Policlinico,Mangiagal Department of Neurosurgery,Washington University,St Louis,MO,USA

会议类型: 国际会议

会议名称: The 3rd International Conference on Bioinformatics and Biomedical Engineering(iCBBE 2009)(第三届生物信息与生物医学工程国际会议)

会议地点: 北京

会议语种:英文

页码: 1-3

在线出版日期: 2009-06-11（万方平台首次上网日期，不代表论文的发表时间）