The Study of Subharmonics Generation Emitted from Microbubble for Monitoring of HIFU Therapy
Cavitation bubbles have aroused mush attention for their significant promise in ultrasonic contrast imaging, targeted therapy and monitoring of high-intensity focused ultrasound (HIFU) therapy. In this paper, a model using a dual-frequency driving pressure for subharmonics generation from cavitation bubbles is constructed. By calculation of the Fourier transformation to the Keller-Milksis equation, we show that bubbles with appropriate radii produce significant subharmonic components within backscatter spectrum. In contrast to the case of single-frequency driving pressure, subharmonics at dual-frequency driving pressure can be generated for higher value of mechanical index (MI) and wider range of initial radii of bubbles. The subharmonic wave is not easy to be absorbed by soft tissues during its propagation compared with higher harmonic wave, and thus subharmonic mode-imaging method for monitoring HIFU therapy maybe has a potential application in providing proper signal-to-noise ratio.
Subharmonic dual-driving driving HIFU therapy signal-to-noise ratio
Jiwen Hu Shengyou Qian
College of Mathematics and Physics Nanhua University Hengyang 421001,P.R.China College of Physics an College of Physics and Information Science Hunan Normal University Changsha 410081,P.R.China
国际会议
北京
英文
1-4
2009-06-11（万方平台首次上网日期，不代表论文的发表时间）