Simulate Heart Failure by A Mathematical Model
Heart failure is simulated using a cardiovascular system model with embedded autonomic nervous regulation and renal blood volume adjustment. The main cardiovascular parameters under heart failure are set as reducing the left ventricular myocardial maximum elasticity by 50％, increasing sympathetic nerve activity by 20％ and decreasing vagus nerve activity by 80％, increasing peripheral resistance by 60％ and decreasing vascular compliance by 25％. The simulation results show that compared with normal condition, in heart failure the cardiac output (CO) reduced from 5.832L/min to 5.767L/min, the eject fraction (EF) reduced from 63.31％ to 43.65％ and left ventricular wall thickness (LVWT) increased from 10mm to 13.70mm. These results generally agree with physiological and pathological features of human heart failure.
Heart failure Cardiovascular model Carotid baroreflez Renal blood volume adjustment
Yuexian Gong Qijun Hu Gangmin Ning Shijin Gong Jing Yan
Dept.of Biomedical Engineering Zhejiang University Hangzhou,China Zhejiang Hospital Hangzhou,China
国际会议
北京
英文
1-4
2009-06-11（万方平台首次上网日期，不代表论文的发表时间）