Age-Related Changes in Viscoelasticity of Rabbit Knee Articular Chondrocytes
Articular chondrocytes undergoes age-related changes that increase the risk of joint degeneration. The goal of this study was to characterize the changes of viscoelastic properties of rabbit chondrocytes in nature degeneration of knee articular cartilage. The micropipette aspiration combined with a standard linear viscoelastic solid model was used to quantify changes in viscoelastic properties of chondrocytes isolated from different age groups. Results have shown that the viscoelastic properties of chondrocytes in old group exhibited a significantly lower instantaneous modulus, equilibrium modulus, and apparent viscosity compared with young group (p<0.005) and adult group (p<0.005). But no differences were found between young group and adult group (p>0.1). These findings may be relevant for chondrocyte-based cartilage tissue engineering.
age-related chondrocyte viscoelastic property micropipette aspiration
Zhang Quanyou Chen Weiyi
Department of Engineering Mechanics,College of Sciences Taiyuan University of Technology Taiyuan,Chi Institute of Applied Mechanics and Biomedical Engineering Taiyuan University of Technology Taiyuan,C
国际会议
北京
英文
1-3
2009-06-11（万方平台首次上网日期，不代表论文的发表时间）