Ezpressions of Notch1 and Cyclin D1 in Breast Hyperplasia and Cancer

摘要：

Expressions of Notch1 and Cyclin D1 were analysed by immunohistochemical method in the specimens of normal mammary tissue, usual hyperplasia, atypical hyperplasia, cancer in situ, and invasive cancer tissue, which were obtained from the patients operated due to some kind of breast disease. We observed an evidently decreased Notch1 and increased cyclin D1 expression respectively from normal tissue to invasive cancer, and a negative correlation was drawn between Notch1 and Cyclin D1.No correlation was found between Notch1 expression and any clinicopathologic parameter, but there was positive correlation between the Cyclin D1 expression and ER. This indicated the inhibiting function of Notch1 and promoting function of Cyclin D1 in proliferating process of mammary ductal tissue. From hyperplasia to cancer, there is a continus and sequential process, which suggest an intimate relationship between mammary hyperplasia and breast cancer.

关键词： mammary ductal hyperplasia invasive mammary cancer Notch1 Cyclin D1 immunohistochemistry

作者: Jin Ke Li-Fen Wang Xiao-Feng Tian

作者单位: Department of surgery Xinhua Hospital,Dalian University Dalian,116023,China Department of pathology and surgery Second Affiliated Hospital,Dalian Medical University Dalian,1160

会议类型: 国际会议

会议名称: The 3rd International Conference on Bioinformatics and Biomedical Engineering(iCBBE 2009)(第三届生物信息与生物医学工程国际会议)

会议地点: 北京

会议语种:英文

页码: 1-3

在线出版日期: 2009-06-11（万方平台首次上网日期，不代表论文的发表时间）