The Inhibitory Effects of Chinese Herbal Effective Fractions on the Ezpression of EBV Early Antigen
With the application of the immune enzyme assay, the inhibitory effects of Chinese herbal effective fractions on the expression of Epstein-Barr virus (EBV) early antigen in Raji cell have been investigated. The test result shows that Astragalus polysaccharide (AP), Ganoderma lucidum polysaccharide (GLP) and Epimedium polysaccharide (EP) have inhibitory effects in certain range of dose. AP and GLP have significantly better inhibitory effects than EP. In addition, the inhibitory effects of these polysaccharides on EBV antigen expression have presented dose-effect relationships. In conclusion, this method can be used for finding new anti-EBV drugs in natural medicine. New anti-EBV drugs will inhibit EBV antigen expression and prevent cell carcinogenesis, so that they will be used for prevention and treatment of EBV associated disease. Furthermore the experiment reveals a new mechanism of herbal polysaccharides anti-viral and anti-tumor effects.
Chinese herbal effective fraction Astragalus polysaccharide Ganoderma lucidum polysaccharide Epimedium polysaccharide Epstein-Barr virus (EBV)
Lv Xiuhua Liu Wei Hao Dongmei Liu Qiaoli Li Zelin Zeng Yi
College of Life Science & Biotechnology,Beijing University of Technology,Beijing 100124
国际会议
北京
英文
1-4
2009-06-11（万方平台首次上网日期，不代表论文的发表时间）