A Mathematical Model of the Dynamics for Anti-HBV Infection Therapy with Chinese Herbs + Adefovir Dipivozi
Based on a patients anti-hepatitis B virus (HBV) infection therapy clinical data of a new type of Chinese herbs (NTCH, consisting of 13 ingredients) plus adefovir dipivoxil, and our previous modified basic virus infection model 1, a new differential equation model with an immune variable is set up, and aims to describe and understand the dynamics of host cells, viruses, the immune system, as well as predict the long term curative effects. The results of numerical simulations of the model indicate that the dynamics of the model is agreement with in the patients plasma HBV DNA levels. The model predicts that it need to eliminate all HBV virus in infected hepatocytes. Otherwise earlier cessation of the therapy will make the patients plasma HBV DNA levels return.
Hepatitis B Chinese Herbs Adefovir Dipivozi anti-HBV infection therapy model
Lequan Min Yongan Ye
Applied Science School,University of Science and Technology Beijing Beijing 100083,PR China Dongzhimen Hospital Beijing University of Chinese Medicine Beijing 100700,China
国际会议
北京
英文
1-4
2009-06-11（万方平台首次上网日期，不代表论文的发表时间）