Stepwise Confidence Intervals Procedures for Tozicological Studies from Grouped Samples

摘要：

In toxicological studies,it is desirable for a method to not declare a higher dose to be safe if it does not declare a lower dose to be safe, Hsu and Berger(1999)and Tao, guo and Shi(2002)s stepwise confidence interval method were recently proposed for this purpose.However, their procedure necessitates the exact values of the observations under normal population. In this article, we propose a stepwise confidence interval method from grouped samples. In addition, we have given a proof that the family-wise type Ⅰ rate can be controlled at the pre-chosen nominal level. An example is used to illustrate our method.

关键词： Grouped samples Likelihood confidence interval Practical equivalence Stepwise confidence interval procedure Tozicity evaluation

作者: Gang Yu Weiguo Wang

作者单位: School of Mathematics and Quantitative Economics Dongbei University of Finance and Economics Dalian,China 116025

会议类型: 国际会议

会议名称: The 3rd International Conference on Bioinformatics and Biomedical Engineering(iCBBE 2009)(第三届生物信息与生物医学工程国际会议)

会议地点: 北京

会议语种:英文

页码: 1-3

在线出版日期: 2009-06-11（万方平台首次上网日期，不代表论文的发表时间）