Fluz Balance Analysis Within Physiologically Feasible Region

摘要：

Flux balance analysis (FBA) has emerged as an effective means to quantitatively analyze cell steady-state metabolic behaviors. However, regardless of environmental factors, basal FBA predictions usually represent the theoretical capabilities of the cell which may not be biologically meaningful. This study proposes a physiological state-oriented FBA, which first estimates physiologically feasible region based on powerful 13C labeling experiment, then FBA is performed within this region. Taking physiological state into account, the proposed strategy is able to produce more biologically meaningful results to accurately characterize cellular metabolic behaviors. The proposed method is further supported by the experimental results of Escherichia coli under oxidative stress condition.

作者: Haoran Zheng Hong Zhou Tie Shen Bin Rui

作者单位: Department of Computer Science and Technology,University of Science and Technology of China Hefei,23 School of Life Science,University of Science and Technology of China Hefei,230027,China

会议类型: 国际会议

会议名称: The 3rd International Conference on Bioinformatics and Biomedical Engineering(iCBBE 2009)(第三届生物信息与生物医学工程国际会议)

会议地点: 北京

会议语种:英文

页码: 1-4

在线出版日期: 2009-06-11（万方平台首次上网日期，不代表论文的发表时间）