OligoChip To Identify HLA-B*5101: Association Study In Male Patients with Behcets Disease
To investigate the association of HLA-B*5101 and male Behcets disease (BD). HLA-B51 antigens and HLA-B51 allele genotyping in 27 BD patients and 53 healthy controls were performed by complement-dependent microlymphocyte toxicity assay, OligoChip and PCR-sequence specific primer (SSP) method. HLA-B51 was found in 63％( 17/27) of BD patients and in 15.1％ (8/53) of controls<0.0001，OR=11.7, 95％CI 3.9-35.4）.All of HLA-B51 antigen positive patients and controls were HLA-B*5101.The genotype frequency of HLA-B*5101 allele was significantly increased in males (42.3％ in females versus 80％ in males), with an OR of 5.6 (95％CI 1.1-29.3, P<0.05). Similar to other groups, HLA-B*5101 might be a susceptible gene for BD, and it was strongly correlated with male BD.
Behcet’s disease HLA-B*5101 OligoChip
Zheng Yan Sun Yuping Wang Yunshan Tian Yufeng Sun Hongsheng
Jinan Central Hospital Affiliated to Shandong University,Jinan,Shandong 250013,P.R.China No.126,Taian Road,Rizhao,Shandong 276826,P.R.China Department of Rheumatology,Shandong Peoples Hospital,Jinan,Shandong 250013,P.R.China
国际会议
北京
英文
1-3
2009-06-11（万方平台首次上网日期，不代表论文的发表时间）