Cytokine network of pulmonary fibrosis with linear differential model and meta-analysis
Objective To evaluate cytokine network of pulmonary fibrosis. Methods A systematic literature search of EMBASE, MEDLINE, Cochrane Library was conducted through December 2007. Then potential regulatory pathway of cytokines was analyzed with a cubic spline intepolation and a linear differential model.The cytokines of silicosis fibrosis tissue were identified by meta-analysis. Results The related cytokines participated pulmonary fibrosis were γ-IFN, IL-10, IL-13, IL-18, IL-4, IL-5,IL-6,IL-8,IGF-1, MCP-1, PDGF, TGF-β1, tNF-α,MMP-2, MMP-9, EGF by meta analysis. The key cytokines of regulated pathway nodes were γ-IFN,IL-10,IL-13,IL-18, IL-6,IGF-1, PDGF, TGF-β1, tNF-α. Conclusion The cytokines networks of pulmonary fibrosis were composed of the key cytokines, but the other cytokines werent in the networks due to minor effectiveness induced pulmonary fibrosis or merely inflammatory effectiveness.
pulmanary fibrosis meta analysis linear differential model regulatory network
GAO Hong-sheng ZHANG Shuang-de WANG Shi-xin
TianJin Key Laboratory of Occupational and Environmental Hazards Biomarkers Medical college of Chinese peoples Armed Police Force Tianjin,China
国际会议
北京
英文
1-4
2009-06-11（万方平台首次上网日期，不代表论文的发表时间）