Assessment of Caenorhabditis elegans germline cell cycle arrest and apoptosis for heavy metals tozicity testing

摘要：

Cadmiun (Cd) and Copper (Cu) are common transition metals found in the environment. The toxic effects of Cd on human health have received considerable concerns. Cu is the trace essential element, however, excess amounts of copper causes toxic effects to life. To have a better understand of the impacts of heavy metals exposure on human beings as well as other animals, many bioassay systems have been developed. In the present study, we show here that Cd and Cu exposure cause dose-and time-dependent germline cell cycle arrest and apoptosis in C. elegans. And, these sublethal endpoints provide useful alternatives for heavy metals toxicity testing with C. elegans.

关键词： Caenorhabditis elegans heavy metals cell cycle arrest apoptosis germline

作者: Shunchang Wang Xun Luo Lijun Wu

作者单位: School of Life Science Huainan Normal University Huainan,Anhui,PR China Key Laboratory of Ion Beam Bioengineering Institute of Plasma Science,CAS Hefei,Anhui 230031,PR Chin

会议类型: 国际会议

会议名称: The 3rd International Conference on Bioinformatics and Biomedical Engineering(iCBBE 2009)(第三届生物信息与生物医学工程国际会议)

会议地点: 北京

会议语种:英文

页码: 1-4

在线出版日期: 2009-06-11（万方平台首次上网日期，不代表论文的发表时间）