Antitumor Activity of Escin in Mice Cervical Carcinoma U_(14) in vivo and Human Cervical Carcinoma Hela Cell Line in vitro
Pollution made cancer a major disease threatening peoples health. In the search for new cancer drug treatments, natural products perform an essential role. Escin, a mixture of triterpene saponins extracted from Aesculus Wilsonii Rehd., was used to analyze the cell growth inhibitory effects and the induction of apoptosis in human cervical carcinoma Hela cancer cell line in vitro. The results of MTT cell viability assay showed that escin could induce significant concentration-dependent and time-dependent inhibition of cell growth, and the cell cycle was arrested at G1/S phase in the escin-treated cells. Apoptosis were detected and assessed by Acridine Orange/Ethidium Bromide Staining and Flow Cytometry. The antitumor efficacy of escin on mice cervical carcinoma U_(14) in vivo was investigated, at dose of 2.8 mg/kg escin had rather high inhibition ratio(43.5％) on U_(14) tumor growth.
escin antitumor activity cervical carcinoma Hela cervical carcinoma U_(14) inhibition cell cycle arrest apoptosis
Xueying Zhou Changhai Wang Fenghua Fu
Department of Bioscience and Biotechnology,Dalian University of Technology,Dalian 116024,China Schoo Department of Bioscience and Biotechnology,Dalian University of Technology,Dalian 116024,China Schoo School of Pharmacy,Yantai University,Yantai,264005,China
国际会议
北京
英文
1-4
2009-06-11（万方平台首次上网日期，不代表论文的发表时间）