Hypolipidemic effect and safety of ursolic acid glycoside esters

摘要：

To investigate the effect of ursolic acid glycoside esters (UAGE) on blood lipid of animal and its acute toxicity, UAGE was synthesized and its hHypolipidemic effect was studied. ICR mice were used to build the model of hyperlipoidemia. The ursolic acid glucose ester was feed to the test animal to study the effect of hypolipidemic effect by measurement of the index of total cholesterol(TC), triglyceride(TG) and high density lipoprotein cholesterol(HDL-c). The acute toxicity of UAGE on mice was also observed. The results shown that UAGE remarkably decreased the serum TC、TG and increased the serum HDL-c of mices. The virtually non-toxic dose of UAGE in mice was less than 25 g/ kg.This shown that ursolic acid glucose ester has the function of hypolipidemic effect and has higher safety. It could be developed a new function food components.

关键词： ursolic acid glycoside esters hypolipidemic effect safety

作者: Wei.Zong Hanjun.Ma

作者单位: School of Food and Biological Engineering Zhengzhou University of Light Industry Zhengzhou,China College of Food Engineering Henan Institute of Science and Technology Xinxiang,China

会议类型: 国际会议

会议名称: The 3rd International Conference on Bioinformatics and Biomedical Engineering(iCBBE 2009)(第三届生物信息与生物医学工程国际会议)

会议地点: 北京

会议语种:英文

页码: 1-3

在线出版日期: 2009-06-11（万方平台首次上网日期，不代表论文的发表时间）