Determination of Amozicillin with Novel Rhodanine Ramification by Flow Injection Chemiluminescence

摘要：

3-(4-fluorophenyl)-5-(2-sulfonylphenylazo)-rhodanine (4FRASP) firstly synthesized by the authors was used as chemiluminescence (CL) reagent. In acidic medium, CL was observed when amoxicillin was injected into the mixture of 4FRASP-potassium permanganate. Based on this phenomenon, a flow injection CL method was established for the determination of amoxicillin. The CL intensity was correlated linear with the concentration of amoxicillin over the range of 5.0×10-8 to 2.0×10-5 g.mL-1 and the detection limit was 4.5×10-9 g.mL-1.The relative standard deviation (RSD) was 1.3％ for determination of 1.0×10-6 g.mL-1 amoxicillin (n=11). This method was applied to the determination of amoxicillin in amoxicillin capsules successfully.

关键词： Chemiluminescence Flow injection Rhodanine Amozicillin

作者: Yu Jing-hua Wan Fu-wei Dai Ping Huang Jia-dong Cui Jian-jie

作者单位: College of Chemistry and Chemical Engineering University of Jinan,Jinan,250022,China College of Medicine and Life Sciences University of Jinan,Jinan,250022,China

会议类型: 国际会议

会议名称: The 3rd International Conference on Bioinformatics and Biomedical Engineering(iCBBE 2009)(第三届生物信息与生物医学工程国际会议)

会议地点: 北京

会议语种:英文

页码: 1-4

在线出版日期: 2009-06-11（万方平台首次上网日期，不代表论文的发表时间）