Micronucleus Kinetics Induced by Chromium Triozide in Vicia Faba Root Tip Cells

摘要：

Aim of the present work was to establish the kinetics of micronucleus(MN) induction in Vicia faba root tip cells on the genotoxicity of chromium trioxide(CrO3). The data indicate non-linear association between MN and exposure times in Vicia faba root tip cells. The maximal MN rate occurred at 24 h. The MN rates were increased in Vicia faba root tip cells from dose of 10-8 to 10-1 mol/L with treatment of upgraded degree of CrO3, and regression equations can received by dualistic nonlinear regression analysis. In the context, increased frequency of micronucleated Vicia-cells is a useful biomarker of genotoxic effects that can reflect exposure to CrO3 with clastogenic and aneugenic modes of action.

关键词： Micronucleus Kinetics Chromium Triozide Vicia Faba Root Tip Cells

作者: Jie Zhang Dan Zhang Liang Yong Zhang Ling

作者单位: Key lab of subtropical agriculture and environment,Ministry of Agriculture,Huazhong Agricultural Uni Cancer institute of Jianghan University,School of Life science and Medicine,Jianghan University,Hube Institute of Micobiology,Chinese Academy of Sciences,100101

会议类型: 国际会议

会议名称: The 3rd International Conference on Bioinformatics and Biomedical Engineering(iCBBE 2009)(第三届生物信息与生物医学工程国际会议)

会议地点: 北京

会议语种:英文

页码: 1-3

在线出版日期: 2009-06-11（万方平台首次上网日期，不代表论文的发表时间）