Electromagnetic Pulse Alter Permeability of the Blood-brain Barrier in Rats
The effect of electromagnetic pulse (EMP) exposure on blood-brain barrier (BBB) permeability in rat brain after whole-body exposed or sham exposed to EMP at 200 kV/m for 400 pulses (1 Hz) was investigated. At 1, 3 and 6 h after EMP exposure, disruption of BBB integrity in rat frontal cerebral cortex was detected by transmission electron microscopy and immunohisto-chemistry using lanthanum nitrate and endogenous albumin as vascular tracers respectively. The results showed that in control rat brain, lanthanum nitrate tracer was limited to the capillary lumen, no lanthanum nitrate and albumin tracer extravasation was found. After EMP exposure, lanthanum nitrate ions reached the tight junction, basal lamina and the pericapillary tissue. Sim-ilarly, albumin immunopositive staining was also found in the pericapillary tissue. The changes of BBB permeability were transient, the leakage of BBB was found at 1 h, and reach the peak at 3 h, then began to recover at 6 h after EMP exposure. These results suggest that exposure to EMP at 200 kV/m for 400 pulses (1 Hz) could increase the permeability of BBB in rat frontal cerebral cortex and this change is recoverable.
Guirong Ding Xiaowu Wang Kangchu Li Yongchun Zhou Lianbo Qiu GuoZheng Guo
Department of Radiation Medicine,School of Public Health Fourth Military Medical University,Xian 710032,China
国际会议
Progress in Electromagnetics Research Symposium 2009(2009年电磁学研究新进展学术研讨会)(PIERS 2009)
北京
英文
1106-1108
2009-03-23（万方平台首次上网日期，不代表论文的发表时间）