The Weak Combined Magnetic Fields Reduce the Brain β-Amyloid in an Animal Model of Sporadic Alzheimers Disease
Subchronic effect of weak combined magnetic fields (MFs) on spatial memory and level of brain β-amyloid (βA) was studied in mice with ablation of the olfactory bulbs and control sham-operated (SO) animals. The bulbectomized (BE) mice show the main signs of Alzheimers type degeneration such as memory impairment, the increase of the βA level in the brain, pathology in the acetylcholinergic system, and the loss of neurons in the brain structures responsible for memory 5-7, 9. The combined MFs consisted of the constant component 42 μT and of the variable component 0.08 μT The variable field was the sum of two signals of frequencies of 4.38 and 4.88 Hz. Exposure to the MFs (4 hours for 10 days) induced the reduction of the βA level in the brain of the BE mice, but did not protected their memory from impairment. However, the same MFs improved the spatial memory in SO mice. The beneficial effect of the MFs in the SO animals was prolonged and was revealed for a month after exposure to the MFs. The results suggest that the MFs can be used to prevent the Alzheimers disease in a group of risk as well as in other diseases involving amyloid protein deposition in different tissues.
N.V.Bobkova V.V.Novikov N.I.Medvinskaya, I.Yu.Aleksandrova E.E.Fesenko
Institute of Cell Biophysics,Russian Academy of Sciences,Pushchino 142290,Russia
国际会议
Progress in Electromagnetics Research Symposium 2009(2009年电磁学研究新进展学术研讨会)(PIERS 2009)
北京
英文
1148-1152
2009-03-23（万方平台首次上网日期，不代表论文的发表时间）