Weak Combined Magnetic Field Accelerates Hydrolysis of βAmyloid-Protein in vitro
Previously, we determined that weak combined magnetic fields substantially accel-erate the spontaneous hydrolysis of some proteins and peptides into fragments in solutions. Here we have shown that a weak combined variable magnetic field of 0.05 μT with frequencies 3.58-4.88 Hz and constant magnetic field of 42 μT accelerate the hydrolytic decomposition of β-amyloid in solution. The region of the molecule that is most sensitive to the weak magnetic field was determined. This region is located between residues Asp7 and Ser8. In this region the hydrolysis of β-amyloid under the action of the magnetic field takes place. It is known that β-amyloid is the key neurotoxic protein in the brain of patients with the Alzheimers disease, accompanied by loss of memory and death. At present one of the main elements of the current strategy of AD treatment involves the active modification of the structural-functional characteristics of protein and peptide molecules participating in the pathological process. Therefore our results can form the basis for new approaches to treatment the diseases related to the accumulation of pathological proteins in different pathologies, including the Alzheimers disease.
E.E.Fesenko V.V.Novikov N.V.Bobkova
Institute of Cell Biophysics,Russian Academy of Sciences Pushchino,Moscow Region 142290,Russia
国际会议
Progress in Electromagnetics Research Symposium 2009(2009年电磁学研究新进展学术研讨会)(PIERS 2009)
北京
英文
1153-1155
2009-03-23（万方平台首次上网日期，不代表论文的发表时间）