New Development and Requirement of Indole Chemistry-Syntheses of Indolenine Derivatives

摘要：

1.Introduction Indolenine itself has never been isolated,however,its derivatives are important intermediates in synthetic organic chemistry.Regioselective β-allylation of indole can be a pivotal step in many synthetic approaches toward the total synthesis of natural products,1,2 In the course of our studies toward the total synthesis of complex alkaloids which possess medicinal bioactivities,we realized that none of reported methods could transform functionalized indoles into β-Allyl indolenines under a mild condition.3-5 Recently,we have reported a general,high-yielding method for the palladium-catalyzed allylation of carba-and heterocycle fused indoles,including complex natural product substrates.6 Additional information about this research will be revealed in the lecture.

关键词： Indole β-Allylation Palladium Alkaloid

作者: Natsuko Kagawa Jeremiah P. Malerich Ye Zhu Viresh H. Rawal

作者单位: Graduate School of Materials Science,Nara Institute of Science and Technology (NAIST),8916-5,Takayam Department of Chemistry,University of Chicago,5735 South Ellis Avenue,Chicago,Illinois 60637,USA

会议类型: 国际会议

会议名称: 18th International Symposium on Fine Chemistry and Functional Polymers,4th IUPAC International Symposium on Novel Materials and Their Synthesis(第18届国际精细化学和功能高分子学术讨论会暨第四届IUPAC 国际新型材料及其制备学术讨论会)

会议地点: 江苏镇江

会议语种:英文

页码: 76-77

在线出版日期: 2008-10-15（万方平台首次上网日期，不代表论文的发表时间）