Synthesis and Characterization of Albumin-Chitosan Bioconjugate

摘要：

1.Introduction Polysaccharide-protein combinations have generated increasing interest for biomedical applications in recent years 1. Chitosan, a naturally derived polysaccharide, is reported to be biocompatible, biodegradable and low toxicity. Availability of numerous amino and hydroxyl groups allows chitosan to be conjugated with antiviral, antimicrobial, antitumor, and anticoagulant agents, as well as peptides and collagen. Moreover, chitosan has been extensively studied for biomedical applications such as drug delivery and tissue repairing 2. For example, chitosan has been catalyzed coupling with peroxidase, cytochrome c, pepstatin A and green fluorescent protein (GFP) by tyrosinase, and the biological activities of the proteins were retained 3, 4 Chitosan has also directly linked with pepstatin A using EDAC as coupling reagent 5.

关键词： bioconjugate chitosan albumin

作者: Naipu He Yufeng He Huifang Zhang Rongmin Wang

作者单位: Key Laboratory of Polymer Materials of Gansu Province,College of Chemistry and Chemical Engineering,Northwest Normal University,Lanzhou 730070,China

会议类型: 国际会议

会议名称: 18th International Symposium on Fine Chemistry and Functional Polymers,4th IUPAC International Symposium on Novel Materials and Their Synthesis(第18届国际精细化学和功能高分子学术讨论会暨第四届IUPAC 国际新型材料及其制备学术讨论会)

会议地点: 江苏镇江

会议语种:英文

页码: 109-110

在线出版日期: 2008-10-15（万方平台首次上网日期，不代表论文的发表时间）