Solid-Phase Synthesis of N-Linked Glycans

摘要：

1.Introduction Asparagine-linked oligosaccharides (N-glycans) are the most prominent in terms of diversity and complexity among the various types of oligosaccharides.They are involved in a variety of important physiological events,such as cell-cell recognition, adhesion,signal transduction,quality control, and circulatory residence of proteins,lthough synthesis of N-glycans has been investigated to evaluate their biological function, an efficient approach to these complex oligosaccharides has yet to be established in terms of (i) selectivity in the glycosyl bond formations,i. e.,-mannosylation and -sialylation, and (ii) a non-tedious purification process during each step of glycosylation and deprotection.

关键词： solid-phase synthesis oligosaccharide N-glycan glycosylation microfluidic system

作者: Koichi Fukase Katsunori Tanaka Yohei Fujii Hiroomi Tokimoto Yasutaka Mori Shin-ichi Tanaka Guang-ming Bao Eric R.O.Siwu

作者单位: Department of Chemistry,Graduate School of Science,Osaka University,Toyonaka,Osaka,560-0043,Japan

会议类型: 国际会议

会议名称: 18th International Symposium on Fine Chemistry and Functional Polymers,4th IUPAC International Symposium on Novel Materials and Their Synthesis(第18届国际精细化学和功能高分子学术讨论会暨第四届IUPAC 国际新型材料及其制备学术讨论会)

会议地点: 江苏镇江

会议语种:英文

页码: 120-121

在线出版日期: 2008-10-15（万方平台首次上网日期，不代表论文的发表时间）