Study on the Synthesis and Property of Narrow Distribution Low Polymerization Degree Chitosan with Gd-DTPA MRI Complezses

摘要：

Gd-DTPA (Magnevist,1) is a clinical MRI contrast agent,with an excellent magnetic property and good stability.However, the recently study revealed that 1 can act as a specific trigger for the development of nephrogenic fibrosing dermopathy and nephrogenic systemic fibrosis, and some countries have been stopped clinical use.It is a new tactic how to keep the excellent property and avoid renal disease,some tentative maneuvers have been explored,such as linking 1 with feasible polysaccharide and protein as well as enwrapped with polymer.Here we report that 1 derivative compounds with series narrow distribution chitooligosaecharides (CTSx-Gd-DTPA) and glucosamine (GLU-Gd-DTPA,2),using 1 as control.The magnetic properties were tasted on NMI20-Analyst(NMR Analyzer with Imaging,22 MHz,Shanghai Niumag Corp.),found DP=8 (CTS8-Gd-DTPA,3) with the best magnetic property,brief introduced as below:

作者: Haipo Gu Qi Zhang Jingbo Wu Lei Chen

作者单位: College of Chemistry and Engineering Niumag MRI study and Application Center,Jiangsu University,Zhen Key Study Center of the National Ministry of Education for Tropical Resources Utilization/Hainan Pro

会议类型: 国际会议

会议名称: 18th International Symposium on Fine Chemistry and Functional Polymers,4th IUPAC International Symposium on Novel Materials and Their Synthesis(第18届国际精细化学和功能高分子学术讨论会暨第四届IUPAC 国际新型材料及其制备学术讨论会)

会议地点: 江苏镇江

会议语种:英文

页码: 133-135

在线出版日期: 2008-10-15（万方平台首次上网日期，不代表论文的发表时间）