Controlled Synthesis of Polylatides using Biogenic Creatinine Carbozylate Initiators

摘要：

1.Introduction In recent years the design and tailoring of biocompatible and biodegradable polymers have attracted considerable attention due to the increasingly demand of the pharmaeeutics and the biomedical science for bioresorbable materials. Polylactides (PLAs), homo-or eopolymers derived from lactides (LA) and glycolide, have found significant biomedical applications as resorhable sutures, drug-delivery carriers, artificial materials for tissue reconstruction and so forth. PLAs are prepared predominantly through ring-opening polymerization (ROP) of the corresponding cyclic esters. Stannous octoate Sn(Oct)2 is a widely and commercially used catalyst. The tin(Ⅱ) catalyst shows high catalytic efficiency in general, however its cytotoxicity has recently aroused increasingly deep concern about the biosafety of materials synthesized with it and use for man-purpose. Seeking tin-free catalysts of highly biosafety is a new challenge in this field. The design of metal-free organic initiators to realize the controlled synthesis of biodegradable polymers have recently attracted considerable interest and attention. Biodegradable polymers used for man-purse should be free of metals. Our work has focused on the design of guanidine-based initiators for the controlled synthesis of biodegradable polymers1,2. Guanidine is non-toxic organic base. Creatinine (CR) is a guanidine derivative participates in the human metabolism. Recently we synthesized two ereatinine carboxylates, I.e. Creatinine acetate (CRA) and ereatinine glycolate (CRG), and found that the two biogenic organic compounds effectively initiate the living ROP of lactides (Scheme 1).

关键词： biodegradable polymer organic initiators creatinine acetate creatinine glycolate

作者: Hong Li Jieping Jiao Zhifeng Jiao Lijun Kong Saihui Zhang Jie Xu Jinlin Li Jiaqing Zuo Xiaona Zhao

作者单位: Key Laboratory of Functional Polymer Materials of Education Ministry,Institute of Polymer Chemistry,Nankai University,Tianjin 300071

会议类型: 国际会议

会议名称: 18th International Symposium on Fine Chemistry and Functional Polymers,4th IUPAC International Symposium on Novel Materials and Their Synthesis(第18届国际精细化学和功能高分子学术讨论会暨第四届IUPAC 国际新型材料及其制备学术讨论会)

会议地点: 江苏镇江

会议语种:英文

页码: 147-149

在线出版日期: 2008-10-15（万方平台首次上网日期，不代表论文的发表时间）