Smart Drug Delivery of Organic/Inorganic Hybrid Calcium-Alginate Beads
1.Introduction Smart polymers are a kind of polymers that show a remarkable change in their properties as a response to slight changes in the surrounding environment such as pH, temperature and ionic strength.Much research has been done to associate biopolymers (such as alginate and chitosan) with thermo-sensitive maeromolecules in an attempt to prepare matrixes that present a dual sensitivity to both pH and temperature.In this work,UV-induced graft polymerization of NIPAAm was performed on the surface of pH-responsive biomineralized polysaccharide-coated Ca-alginate beads to produce a new kind of pH/temperature sensitive drug delivery system.As illustrated in Scheme 1,PNIPAAm on the surface acts as on-off gate to control the smart release of the entrapped drug.The purpose of biomineralized polysaccharide-coating in this study is to improve the strength and sustain the drug release rate of Ca-alginate beads in a neutral pH condition.
alginate PNIPAAm drug delivery systems stimuli-sensitive polymers
Jun Shi Xiaopei Liu Shaokui Cao
School of Materials Science and Engineering,Zhengzhou University,Zhengzhou 450052,China
国际会议
江苏镇江
英文
157-159
2008-10-15（万方平台首次上网日期，不代表论文的发表时间）