Improving sequence alignment using class-specific score matrices
Sequence alignment has been a most commonly used method in modern biological research. However, Sequence alignment in Twilight Zone is still a challenging issue. Three protein class-specific matrices are constructed to investigate whether alignment in Twilight Zone can be improved by using class-specific matrices and gap penalties. The substitution pattern differences between different protein classes do improve the performances of the three class-specific matrices. Analyzing amino acids substitution pattern based on different matrices also suggests important information for protein sequence design.
Sequence alignment score matriz class-specific substitution pattern
Hai Song Xu Wen Ke Ren Xiao Hui Liu Xiao Qin Li
College of Life Science and Bioengineering Beijing University of Technology Beijing, 100022, China
国际会议
上海
英文
70-73
2008-05-16（万方平台首次上网日期，不代表论文的发表时间）