Synthesis of lactosylated piperazinyl porphyrin and Its Interaction with DNA

摘要：

A water-soluble lactosylated piperazinyl porphyrin, 5-mono4-(4-lactobionylaminopiperazinyl)-phenyl-10,15,20-triphenyl-porphyrin (MLPP), was synthesized basing on the porphyrins special affinity for cancer cells and the antitumor activity of piperazine compounds. Its structure was characterized by UV-Vis spectra, elemental analysis and 1H NMR. A model for the interaction between MLPP and DNA was built, and the binding mechanism between MLPP and cell molecules was investigated by UV-Vis spectra and fluorescence spectrum.

关键词： 5-mono4-(4-lactobionylaminopiperazinyl)- phenyl-10,15,20-triphenyl-porphyrin calf thymus DNA synthesis interaction

作者: Heping Li Zhoudong Wang

作者单位: College of Chemistry and Environmental Engineering, Changsha University of Science and Technology, Changsha, 410076, P.R.China

会议类型: 国际会议

会议名称: The 2nd International Conference on Bioinformatics and Biomedical Engineering(iCBBE 2008)(第二届生物信息与生物医学工程国际会议)

会议地点: 上海

会议语种:英文

页码: 113-116

在线出版日期: 2008-05-16（万方平台首次上网日期，不代表论文的发表时间）