An Analysis of Non-coding RNA Using Z-curve Method
It has very important significance to research noncoding region and its function. The Z curve is a very useful method for visualizing and analyzing DNA sequences. It is a three-dimensional space curve constituting the unique representation of a given DNA sequence in the sense that each can be uniquely reconstructed from the other. Based on the Z curve, a new non-coding RNA-finding method for some diseaserelated ncRNAs has been proposed. We select two different types of Specific ncRNAs-BC200 RNA and H19 RNA from the NONCODE database, which relate with diseases Alzheimer and Beckwith-Wiedemann Syndrome,respectively.The corresponding Z curves of the ncRNAs sequences have some special geometrical features. These features can be regard as a criterion to recognize different disease-related ncRNAs.
non-coding ncRNA Z-cueve base content disparity
Yan-ling Yang Ji-hua Wang Jia-feng Yu Gui-zhong Liu
Key Lab of Biophysics in University of Shandong, Dezhou Shandong 253023 College of Physics & Electro Key Lab of Biophysics in University of Shandong, Dezhou Shandong 253023
国际会议
上海
英文
129-132
2008-05-16（万方平台首次上网日期，不代表论文的发表时间）