Hydrophobic Amino Acid Composition Patterns Over Secondary Structure Elements of Proteins

摘要：

As evidenced by a buried core of hydrophobic residues within globular proteins, hydrophobicity provides essential insights into the folding structure of proteins. Previous studies have shown that hydrophobic residues show statistically meaningful distribution on the primary sequence, but most of them lacked further investigation into a potential relationship to secondary structure elements. In this paper we experimentally show that the hydrophobic residues collectively reveal different composition patterns over different secondary structure elements. After visually presenting the class-specific features, we quantitatively compare them using the statistical moments.

关键词： component Protein Secondary Structure Physicochemical properties of amino acid Hydrophobicity

作者: Gouchol Pok MingHao Piao Seung Jung Shin Keun Ho Ryu

作者单位: Dept. of Computer Science Yanbian University of Science and Technology Yanji, China 133000 DB/Bioinformatics Lab Chungbuk National University, Cheongju, Korea 361-763 Division of Information Technology Hansei University, Gunpo Korea, 435-742

会议类型: 国际会议

会议名称: The 2nd International Conference on Bioinformatics and Biomedical Engineering(iCBBE 2008)(第二届生物信息与生物医学工程国际会议)

会议地点: 上海

会议语种:英文

页码: 148-151

在线出版日期: 2008-05-16（万方平台首次上网日期，不代表论文的发表时间）