Bipolarity of the Saccharomyces cerevisiae genome
Accumulating evidence indicates that eukaryotic genes tend to belong in two distinct categories that we will call class Ⅰ and class Ⅱ. Class Ⅰ genes do not contain a TATA box in their promoter, and have low expression variability both at the single cell level (in constant environment) and at the population level (in changing environmental conditions). In contrast, class Ⅱ genes contain a TATA box in their promoter, and tend to have pronounced expression variability both at the single cell level (in constant environment) and at the population level (in changing environmental conditions). Here we show that the positioning and regulation of class Ⅰ and class Ⅱ genes is strikingly different in the large-scale transcriptional regulatory (TR) network of S. cerevisiae. We also show that class Ⅰ and class Ⅱ genes differ dramatically in several properties, including gene expression variability at diverse time scales and population sizes, mutational variance, gene essentiality and subcellular localization. This dichotomy might indicate that evolution placed different genes in different locations within the cell and within the TR network, according to some fundamental principles that govern cellular information processing and survival in a changing environment.
Saccharomyces cerevisiae TATA boz bipolarity
Allison P. Heath Lydia Kavraki Gábor Balázsi
Department of Computer Science Rice University Houston, Texas, USA Department of Systems Biology – Unit 950 The University of Texas M. D. Anderson Cancer Center Housto
国际会议
上海
英文
330-333
2008-05-16（万方平台首次上网日期，不代表论文的发表时间）