Association study of 5-HT2A receptor gene polymorphism with persistent somatoform pain disorder and the efficacy of fluozetine
Objective To analyze the association between the 5-HT2A receptor gene polymorphism and persistent somatoform pain disorder in Chinese and to investigate the relationship between the analgesic efficacy of fluoxetine and 5-HT2A receptor gene polymorphism. Method 51 patients with persistent somatoform pain disorder were administered with fluoxetine(20mg/day) for 6 weeks. The response to fluoxetine was assessed by the Medical Outcomes Study Pain Measures (MOSPM). The patients were divided into two groups (responders and non-responders) according to the MOSPM response rate. The T102C polymorphism genotype and allele frequencies of 5-HT2A receptor gene in these 51 patients and 60 healthy controls were detected with PCR-RFLP technique. Results 1.No significant association was found between persistent somatoform pain disorder and 5-HT2A receptor gene T102C polymorphism. 2. In responders group, number of patients with C/C genotype and C allele frequency was significantly higher than that of non-responder group, while the frequency of T/T genotype and T allele was vice versa (p<0.05). Conclusion It indicated that the T102C polymorphism of the 5-HT2A receptor gene was not significant factor associated with persistent somatoform pain disorder, but it may be one predictor of the analgesic efficacy of some SSRIs treatment.
5-HT2A receptor polymorphism persistent somatoform pain disorder fluozetine efficacy
Yanli Luo Wenyuan Wu Chunbo Li Mingyuan Zhang Ye Zhang Sanduo Jiang
Dept. of psychosomatics, Tongji Hospital of Tongji University, Shanghai, China Shanghai Mental Health Center, Shanghai Jiaotong University, Shanghai, China
国际会议
上海
英文
399-401
2008-05-16（万方平台首次上网日期，不代表论文的发表时间）