Marfan syndrome ezon CpG percentage and fractal dimension
The CpG di-nucleotide percentage and exon fractal dimension fluctuation were investigated with respect to the recently identified Marfan syndrome exons in the FBN1 gene. The CpG di-nucleotide percentage was found to rank high in exon 1 (9％), exon 44 (6.5％), exon 24 (5.3％) and exon 27 (4.8％). The most significant Marfan exon group was reported to be exon 24-32. An exon nucleotide sequence can be expressed as a numerical sequence when each nucleotide is assigned its proton number. The resulting exon nucleotide numerical sequence could be investigated for its fractal dimension. The fractal dimension exhibited fluctuation across the 65 FBN1 exons and the values formed a Gaussian-like distribution (N=65). The moving average fractal dimension was found to exhibit a broad peak around exons 24 to 32, consistent with the reported Marfan syndrome exon group.
component : Marfan syndrome ezon CpG dinucleotide percentage, fractal dimension correlation
Todd Holden G. Tremberger, Jr E. Cheung R. Subramaniam R. Sullivan P. Schneider A. Flamholz D. Lieberman T. Cheung
Physics CUNY Queensborogh Community College Bayside, NY 11364 USA Biology Departments CUNY Queensborogh Community College Bayside, NY 11364 USA
国际会议
上海
英文
482-485
2008-05-16（万方平台首次上网日期，不代表论文的发表时间）