An Improved Algorithm for Tag SNP Selection Based on Pair-Wise Linkage Disequilibrium

摘要：

The search for the association between complex diseases and single nucleotide polymorphisms (SNPs) or haplotypes has recently received great attention. For those studies, it is essential to use a small subset of informative SNPs, i.e., tag SNPs, accurately representing the rest of the SNPs. We devised an improved algorithm for tagSNP selection using the pair-wise r2 criterion. We first break down large marker sets into separate partitions, where more exhaustive searches can replace the LDSelect algorithm for tagSNP selection. These exhaustive searches lead to smaller tagSNP sets being generated. Its performance was assessed using HapMap data.

关键词： tag SNP selection association study linkage disequilibrium

作者: Wei Wang Youling Guo Yuexian Zou Tianrui Wu

作者单位: The Key Laboratory of Integrated Microsystems Shenzhen Graduate School of Peking University Shenzhen, Guangdong Province, P.R.China

会议类型: 国际会议

会议名称: The 2nd International Conference on Bioinformatics and Biomedical Engineering(iCBBE 2008)(第二届生物信息与生物医学工程国际会议)

会议地点: 上海

会议语种:英文

页码: 632-635

在线出版日期: 2008-05-16（万方平台首次上网日期，不代表论文的发表时间）