Modelling the Effect of Electric Pulse on Cells and Ezperimental Research
The effect of electric pulse to cells is simulated with a resistor-capacitor(RC) circuit model. The transmembrane voltage equation is deduced from the RC circuit model, which is proposed according to cell model with mitochondria included. The experiment settings are designed to produce pulsed electric field with the intensity peak of 2.12MV/m within 100ns and 1μs, respectively. Cell death rates are assessed after electric stimulation. With the experimental parameters and cell structural, cell electric parameters from related papers, transmembrane voltages of cytomembrane and mitochondria membrane are calculated as the functions of time. Apoptosis can be induced when the mitochondria membrane is electroporated and cell will die in another way from that induced by cytomembrane electroporation. The RC circuit model and calculation correspond with the experiment result.
Electroporation resistor-capacitor circuit model electric pulsed apoptosis
Xufei
School of Electric, Shanghai Dianji University Shanghai China
国际会议
上海
英文
880-882
2008-05-16（万方平台首次上网日期，不代表论文的发表时间）