C2H2 Zinc Finger Nucleotide Fluctuation
A C2H2 zinc finger nucleotide sequence can be expressed as a numerical sequence when each nucleotide is assigned its proton number. A resulting zinc finger numerical sequence could be investigated for its fractal dimension in terms of evolution, multiple finger structure flexibility, and 3-finger structure specificity. The ZNF714 sequence was found to have a fractal dimension higher than its evolutionary ancestor ZNF431, consistent with the recently reported evolutionary direction using traditional analysis. The ZNF91 sequence has 36 zinc fingers and their fractal dimensions form a Gaussian-like histogram, suggesting a maximal flexibility for capacity dimension. The CpG di-nucleotide percentage in the three zinc fingers of EGR1 is found to correlate with the fractal dimension while the five zinc fingers in ZFP91 separated into human-chimp and mouse-ratdog groups. Extension of the fractal investigation to short genetic sequences is discussed.
component c2h2 zinc finger fractal dimension ZNF 174 ZNF431 ZNF91 EGR ZFP91
G. Tremberger, Jr E. Cheung R. Subramaniam R. Sullivan P. Schneider A. Flamholz D. Lieberman T. Cheung Todd Holden
Physics Departments CUNY Queensborogh Community College Bayside, NY 11364 USA Biology Departments CUNY Queensborogh Community College Bayside, NY 11364 USA
国际会议
上海
英文
943-946
2008-05-16（万方平台首次上网日期，不代表论文的发表时间）