Effects of Puerarin on Monoamino Neurotransmitter Levels in the Striatum of Cerebral Ischemia Rats

摘要：

Objective: This study was undertaken to examine the patterns of changes in extracellular fluid (ECF) dopamine (DA), orepinephrine (NE) and serotonin (5-HT) in the striatum of rats with middle cerebral artery occlusion (MCAO). The effect of Puerarin on monoamine neurotransmitter in the MCAO rats was also studied. Methods: Microdialysis was used to sample the brains extracellular space during 80 min of cerebral ischemia followed by 80 min of reperfusion. The microdialysate was measured by high performed liquid chromatography (HPLC). Results: It showed Puerarin could alleviate cerebral ischemia damage.

关键词： Puerarin cerebral ischemia HPLC monoamine neurotransmitter middle cerebral artery occlusion (MCAO)

作者: Li Hui Zheng Xiaoxiang

作者单位: College of Biomedical Engineering and Instrument Science, Yuquan Campus, Zhejiang University Hangzho College of Biomedical Engineering and Instrument Science, Yuquan Campus, Zhejiang University Hangzho

会议类型: 国际会议

会议名称: The 2nd International Conference on Bioinformatics and Biomedical Engineering(iCBBE 2008)(第二届生物信息与生物医学工程国际会议)

会议地点: 上海

会议语种:英文

页码: 1332-1335

在线出版日期: 2008-05-16（万方平台首次上网日期，不代表论文的发表时间）