Preparation, sustained-release and transdermal penetration propertiesof drug-loaded hollow fibers

摘要：

Acyclovir-loaded PAN hollow fibers were prepared with dry-wet spinning processes. The coblending method was employed to prepare the spinning liquid. The prepared hollow fibers had a diameter of 300 m. The drug content in the hollow fibers is lower than that in the spinning liquid, 20.28％ of the drug was lost during the spinning processes. SIn vitro dissolution tests indicated the obvious initial burst effect. Permeability test results illustrated that the permeation of acyclovir is limited by the skin.

关键词： Drug-loaded hollow fibers dry-Wet spinning Drug delivery systems Acyclovir

作者: S.J.Zhu D.G.Yu L.M. Zhu C. Branford-White

作者单位: College of Chemistry, Chemical Engineering and Biotechnology Donghua University Shanghai, China Institute for Health Research and Policy London Metropolitan University London, UK

会议类型: 国际会议

会议名称: The 2nd International Conference on Bioinformatics and Biomedical Engineering(iCBBE 2008)(第二届生物信息与生物医学工程国际会议)

会议地点: 上海

会议语种:英文

页码: 1379-1382

在线出版日期: 2008-05-16（万方平台首次上网日期，不代表论文的发表时间）