Hyper-Chaos and Singular Beats in Congestive Heart Failure: Observation and Simulation
Transient hyper-chaos with extraordinary high strength was observed in HRV of CHF patients by means of numerical titration method based on Volterra-Wiener series. In comparison with healthy subjects, RR series of CHF patients present sporadic impulses composed of normal, rather then premature beats. To illustrate such impulses and its relation to hyper-chaos, a sinoatrial node (SAN) model was developed. Simulations showed that high norepinephrine and low acetylcholine concentrations induced singularity in RR intervals and resulted in hyper-chaos. It is consistent with the high sympathetic and low parasympathetic tones in CHF.
sinoatrial node heart rate variability chaos congestive heart failure model
Cheng LI Da-Kan TANG Guo-Qiang WU Chi-Sang POON
Department of Mechanics and Engineering Science Fudan University Shanghai, P. R. China Harvard-MIT Division of Health Sciences & Technology Massachusetts Institute of Technology Cambridge
国际会议
上海
英文
1449-1452
2008-05-16（万方平台首次上网日期，不代表论文的发表时间）