The Effect of Irradiation Degradation of Chitosan with γ-ray on the Enzymatic Degradability in Vitro of Chitosan-based Biomembrane
The degraded chitosans were obtained with the irradiation of aqueous chitosan/HAc solution by using γ-ray, their viscosity average molecular weights and degrees of deacetylation were determinated with dilute solution viscometry and elemental analysis method, respectively. Four biomembranes prepared separately from chitosans with different viscosity average molecular weight were soaked in aqueous lysozyme/phosphate buffer, and their percentages of weight loss in different time were recorded. The research result indicated that the viscosity average molecular weight of degraded chitosan decreased as the dosage of 60Co γ-ray increased, but degrees of deacetylation retained constant. The percentage of weight loss of chitosan-based biomembrane in lysozyme/phosphate buffer increased as time increased, and increased as molecular weight decreased. Its feasible to improve the biodegradability of chitosan-based biomembrane by lowering the molecular weight of corresponding chitosan.
Chitosan γ-Ray Viscosity Average Molecular Weight Degree of Deacetylation Biomembrane Lysozyme
Bo Liu Yi Guang Wu Zong Kun Zheng Wen Lin Yang Qun Ying Chen Xin Zheng Huang
Faculty of Chemistry and Chemical Engineering Shen Zhen University Shen Zhen, China
国际会议
上海
英文
1507-1509
2008-05-16（万方平台首次上网日期，不代表论文的发表时间）