Fabrication and Characterization of Electrospun Poly (L-lactic acid) and Poly (L-lactide -co -glycolide) Mats as Wound Dressings
Electrospun poly (L-lactic acid) (PLLA) and poly (L-lactide -co -glycolide) (PLGA) mats were fabricated as wound dressings. The in vitro degradation behavior was studied in phosphate buffer solution (PBS, pH 7.4) at 37℃ for 6 days. Structural and morphological changes during degradation were investigated with gel permeation chromatography (GPC) and scanning electron microscopy (SEM). Both of the electrospun biopolymer mats showed stable degradation rate without losing the fibrous structure. Water adsorption ability, water retention ability and water vapor permeability were monitored comparing with PLGA casting film. The results indicates that the electrospun PLLA and PLGA mats are suitable for wound dressing and PLGA mat is more preferable.
electrospinning wound dressing poly (L-lactic acid) poly (L-lactide -co -glycolide)
Shuying Gu Zhimei Wang Jie Ren Chunyan Zhang
Institute of Nano- and Bio- Polymeric Materials School of Materials Science and Engineering, Tongji University Shanghai 200092, China
国际会议
上海
英文
1514-1517
2008-05-16（万方平台首次上网日期，不代表论文的发表时间）