Design of a Novel Acid-sensing Biosensor based on Taste Neurons and LAPS
A novel biosensor based on the platform of neuronsilicon interface was designed and characterized. Taste receptor cells cultured on light addressable potentiometric sensor (LAPS) can recognize sour stimuli as compared with non-acid solutions. A computational model of taste receptor cells was constructed to simulate the ionic currents and action potentials of taste receptor cells, to help decode extracellular signals recorded by LAPS. This study provides the prototype of a novel biosensor which deploys the sensory transduction and decoding mechanism from biology to realize chemosensing, potentially in a noninvasive and longterm manner.
Biomedical Devices Cell-based Biosensor Chemosensing Taste Receptor Cell Ionic Model LAPS
Peihua Chen Gong Cheng Bingqing Wang Ping Wang Xiao-dong Liu
Biosensor National Special Laboratory, Department of Biomedical Engineering, Zhejiang University, 31 Department of Biomedical Engineering and Neuroscience Johns Hopkins University, Baltimore MD 21205,
国际会议
上海
英文
1561-1564
2008-05-16（万方平台首次上网日期，不代表论文的发表时间）