New Target Controlled Infusion Using a Hybrid Physiologically Based Pharmacokinetic Model

摘要：

New target controlled infusion (TCI) for propofol using a hybrid physiologically based pharmacokinetic (PBPK) model was proposed in this paper. The hybrid model was composed of a three-compartment mamillary systemic model and a two-compartment brain model. A closed-loop control algorithm with brain concentration as the control variable was used to calculate the infusion. Finally, the dose regimen was applied in clinical practice and the recorded auditory evoked potentials showed good depth of anaesthesia. The TCI was feasible and had potential applications.

关键词： anaesthesia target controlled infusion (TCI) physiologically based pharmacokinetic (PBPK) model propofol auditory evoked potentials (AEP)

作者: Xuan WANG Yi PAN Hang CHEN Shuming YE Xinzhong CHEN

作者单位: Department of Biomedical Engineering Zhejiang University Hangzhou, China Department of Anesthesia, Womens Hospital School of Medicine, Zhejiang University Hangzhou, China

会议类型: 国际会议

会议名称: The 2nd International Conference on Bioinformatics and Biomedical Engineering(iCBBE 2008)(第二届生物信息与生物医学工程国际会议)

会议地点: 上海

会议语种:英文

页码: 1822-1824

在线出版日期: 2008-05-16（万方平台首次上网日期，不代表论文的发表时间）