Deformation-Based Morphometric Analysis of brain structures in First Episode Schizophrenia
The pathological reason for schizophrenia is still unknown to date. Fortunately, deformation based morphometry (DBM) provides an important tool for the computational anatomy research. In this study we detected the changes of regional volume in brain structures between the first episode schizophrenia (FES) and normal controls with DBM method. Information of the difference is derived from the deformation field acquired during HAMMER non-rigid registration. The experimental results show that contracted regions are mainly located in Brodmann42 and right occipital lobe while the expanded regions are located in Brodmann38, 21, left middle frontal gyrus and left cerebellum. This research is very helpful to make the cause of changes in schizophrenias brain structures clear.
deformation based morphometry first episode schizophrenia non-rigid registration
Chunlan Yang Shuicai Wu Yanping Bai Hongjian Gao
College of life science & Bioengineering, Beijing University of Technology Beijing, China
国际会议
上海
英文
2423-2426
2008-05-16（万方平台首次上网日期，不代表论文的发表时间）